THE RELATIONSHIP BETWEEN THE FUNCTIONALITY OF CHILDREN WITH DISABILITIES AND ITS EFFECTS ON PARENTS DURING THE COVID-19 PANDEMIC PROCESS.

Purpose: The aim of this study was to investigate the relationship between the functionality of disabled children and its effects on parents during the Covid-19 pandemic. Method(s): A total of 168 people, including 84 disabled children and 84 mothers, were included in the study. The Pediatric Disability Assessment Inventory (PEDI) and Gross Motor Function Classification System (GMFCS) were used for children with disabilities. The Zarit Burden Scale (ZBS), Fatigue Severity Scale (FSS) and The Nordic Musculoskeletal Questionnaire (NMQ) were applied to the mothers to question musculoskeletal disorders. Result(s): There was no correlation between care burden score and PEDI, total score, self-care and mobility scores (p>0.05). A moderately negative (r=-0.306;p<0.01) significant linear relationship was found between care burden score and social function score. There was no significant linear relationship between the fatigue severity score and PEDI total score, self-care, mobility and social function scores (p>0.05). No correlation was found between care burden score and fatigue severity score (p>0.05). For the last 12 months, only the pain in the lumbar region of the parents prevented them from doing their usual work. It was determined that the most aching body parts of the parents who complained of musculoskeletal pain during the last 12 months were in the waist, neck, shoulder, back, and knee regions. Conclusion(s): As a result, no relationship was found between the functionality of disabled children and their parents' influences during the Covid-19 pandemic.Copyright © 2022 Turkish Physiotherapy Association. All rights reserved.

The Relationship between the Functionality of Children with Disabilities and Its Effects on Parents during the Covid-19 Pandemic Process

Purpose: The aim of this study was to investigate the relationship between the functionality of disabled children and its effects on parents during the Covid-19 pandemic. Methods: A total of 168 people, including 84 disabled children and 84 mothers, were included in the study. The Pediatric Disability Assessment Inventory (PEDI) and Gross Motor Function Classification System (GMFCS) were used for children with disabilities. The Zarit Burden Scale (ZBS), Fatigue Severity Scale (FSS) and The Nordic Musculoskeletal Questionnaire (NMQ) were applied to the mothers to question musculoskeletal disorders. Results: There was no correlation between care burden score and PEDI, total score, self-care and mobility scores (p>0.05). A moderately negative (r=-0.306;p<0.01) significant linear relationship was found between care burden score and social function score. There was no significant linear relationship between the fatigue severity score and PEDI total score, self-care, mobility and social function scores (p>0.05). No correlation was found between care burden score and fatigue severity score (p>0.05). For the last 12 months, only the pain in the lumbar region of the parents prevented them from doing their usual work. It was determined that the most aching body parts of the parents who complained of musculoskeletal pain during the last 12 months were in the waist, neck, shoulder, back, and knee regions. Conclusion: As a result, no relationship was found between the functionality of disabled children and their parents' influences during the Covid-19 pandemic.

Impact of COVID-19 on Children with Asthma.

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), can give rise to serious and fatal consequences, especially by affecting the lungs. The disease has been reported to have a milder course in children compared to adults, however chronic diseases in children as well as in adults can pose a risk for severe COVID-19 disease. While chronic lung diseases are considered as risk factors especially, there is no clear data yet on whether childhood asthma poses a risk to COVID-19. Besides, changes in the environment, social and health system during the pandemic period have positive and negative effects on the follow-up and disease control of asthmatic children. In this article, the literature has been reviewed for determining the effects of COVID-19 in children with asthma and for the management of pediatric asthma in the pandemic.Copyright © 2021 Ankara Pediatric Hematology Oncology Training and Research Hospital. All rights reserved.

Impact of COVID-19 on Children with Asthma

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), can give rise to serious and fatal consequences, especially by affecting the lungs. The disease has been reported to have a milder course in children compared to adults, however chronic diseases in children as well as in adults can pose a risk for severe COVID-19 disease. While chronic lung diseases are considered as risk factors especially, there is no clear data yet on whether childhood asthma poses a risk to COVID-19. Besides, changes in the environment, social and health system during the pandemic period have positive and negative effects on the follow-up and disease control of asthmatic children. In this article, the literature has been reviewed for determining the effects of COVID-19 in children with asthma and for the management of pediatric asthma in the pandemic.

Impact of COVID-19 on Children with Asthma.

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), can give rise to serious and fatal consequences, especially by affecting the lungs. The disease has been reported to have a milder course in children compared to adults, however chronic diseases in children as well as in adults can pose a risk for severe COVID-19 disease. While chronic lung diseases are considered as risk factors especially, there is no clear data yet on whether childhood asthma poses a risk to COVID-19. Besides, changes in the environment, social and health system during the pandemic period have positive and negative effects on the follow-up and disease control of asthmatic children. In this article, the literature has been reviewed for determining the effects of COVID-19 in children with asthma and for the management of pediatric asthma in the pandemic. Copyright © 2021 Ankara Pediatric Hematology Oncology Training and Research Hospital. All rights reserved.

Evaluation of the clinical and laboratory findings of asthmatic children with SARS CoV-2 infection

Background: There are a limited number of studies about the clinical findings of coronavirus infection in pediatric patients with asthma. We aimed to evaluate the clinical and laboratory characteristics of pediatric patients with asthma and healthy children without chronic disease who were infected with SARS-CoV-2. Method: This is a retrospective, case-control study comparing the children diagnosed with asthma and healthy children who were diagnosed with COVID-19 in our hospital between March,11 and November,10 2020. Results: During the study period, 6205 children were diagnosed with COVID-19 in our hospital. Only 54 (0.87%) patients had a diagnosis of asthma. The mean of the age was 10.7 years and 53.7% (n:29) of the patients with asthma were male. Cough, shortness of breath, emesis and diarrhea were found to be significantly higher in asthma group than in the control group (respectively p = 0.002,0.000, 0.002, 0.019, 0.015). Patients who were given SABA were significantly higher in asthma diagnosed patients (p = 0.000). There was no significant difference between the two groups in terms of oxygen treatment and hospitalization requirement. There was no significant difference in laboratory findings between groups. Conclusion: This study revealed that pediatric patients diagnosed with asthma were in mild clinic state and the clinic of COVID-19 was not different between the groups. According to these findings, asthma may not be a risk factor for the development of COVID-19 and may not affect the course of the disease in children. (Table Presented).

Evaluation of effective risk factors in COVID-19 mortality rate with DEMATEL method

The world has faced Covid-19, a serious threat to human health since the beginning of 2020. Determination of factors affecting Covid-19-related deaths is very important for the fight against virus and has been the subject of many studies. Multi criteria decision making methods support the decision maker to reach an effective result by providing the opportunity to evaluate all factors that may affect the decision problem. In this study, we examined the factors that constitute the risk group of Covid-19 disease in accordance with the multi criteria decision making structure. With DEMATEL (Decision Making Trial and Evaluation Laboratory) method we evaluated the generally accepted factors for the disease from a different perspective. We have compiled data from the literature and identified the factors referenced in various sources. We analyzed the levels of influence of these risk factors, known to be effective on deaths, by making numerical analyzes for different threshold values that we determined according to the spread of the virus. We obtained results that can be taken as a basis in terms of the strategies to be applied for virus spread process. Finally, we interpreted the multi-criteria analysis results in accordance with the basic principles of the DEMATEL method.

Nexus between CNS resident microglia and migrating peripheral T cells pave the way for host immunity against neurotropic virus infection

Neurotropic virus induced neuroinflammation initiates with the activation of brain resident immune cells which causes a heightened release of chemokines/cytokines leading to a compromise in the blood brain barrier integrity. This accentuates the upregulation of regulatory molecules like antiviral Interferon stimulating gene induced tetratricopeptide repeats protein, Ifit2, and augments infiltration of peripheral immune cells. Among the early infiltrating immune cells, a large population is composed of neutrophils and monocyte/macrophages which, along with brain resident microglia, orchestrate the full panoply of innate immune responses. Ifit2 has been shown to be beneficial in protecting mice from lethal neurotropic virus infection by restricting viral replication and amplifying antiviral responses. Using a murine neurotropic coronavirus infection in Ifit2-/- mice, we report that in the absence of Ifit2, viral replication is significantly increased and mice develop severe neuropathy. Despite the enormous viral load, Ifit2-deficient mice are impaired in microglial activation and recruitment of peripheral T cells into the CNS. To further confirm the role of migratory T cells in viral-induced neuroinflammation and neurodegeneration, studies were conducted in CD4-/- mice. Results showed no significant change in acute stage pathogenesis, whereas CD4-/- mice showed accelerated loss of axon-myelin coherence during the chronic stage. Together, studies in Ifit2 and CD4 knockout mice reveal that the interplay between brain resident microglia and migratory helper T cells is important for strengthening host immunity against neurotropic virus infection.